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Calcium and acid rebound: a reappraisal
Journal of Clinical Gastroenterology
|July 1, 1992
Summary
Acid rebound, an increase in stomach acid after antacid use, led to calcium carbonate
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Acid rebound is a paradoxical increase in gastric acid secretion following antacid administration.
- Calcium carbonate's use in peptic ulcer disease declined due to concerns about acid rebound, despite historical efficacy.
- Mechanisms may include direct ionic stimulation or gastrin release via antral alkalinization.
Purpose of the Study:
- To reevaluate the phenomenon of acid rebound.
- To assess the clinical significance of acid rebound, particularly for calcium carbonate in peptic ulcer treatment.
Main Methods:
- Review of existing literature on antacid-induced acid secretion.
- Analysis of studies investigating calcium carbonate and other antacids.
- Examination of clinical data regarding the effects of acid rebound.
Main Results:
- Calcium carbonate demonstrably causes increased gastric acid secretion.
- Evidence for acid rebound with magnesium and aluminum hydroxide is less conclusive.
- Limited clinical data suggest no significant adverse effects from calcium carbonate-induced acid rebound in peptic ulcer patients.
Conclusions:
- The clinical import of acid rebound remains under-investigated.
- Calcium carbonate's efficacy, acid-neutralizing capacity, and potential role in ulcer healing warrant a reevaluation of acid rebound's clinical relevance.
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