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Updated: Aug 25, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Microwave heating of heterogeneously catalysed Suzuki reactions in a micro reactor
Ping He1, Stephen J Haswell, Paul D I Fletcher
1Department of Chemistry, The University of Hull, Hull, UKHU6 7RX.
Abstract:
The Suzuki cross-coupling reaction of aryl halides with phenylboronic acid to form biaryls has been used to illustrate the development of a microwave based technique capable of delivering heat locally to a heterogeneous Pd-supported catalyst located within a micro reactor device. A 10-15 nm gold film patch, located on the outside surface of the base of a glass micro reactor, was found to efficiently assist in the heating of the catalyst when irradiated with 5-7 W of microwave power at 2.45 GHz. Using a hydrodynamically pumped system, reactant-catalyst contact times of less than 60 s were found to give conversions for different substrates which were in the range 50-99%. Two methods of loading catalysts into the micro reactor were investigated which required either 1.5 or 6 mg of material.
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