Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An integrated optical oxygen sensor fabricated using rapid-prototyping techniques.

David A Chang-Yen1, Bruce K Gale

  • 1Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84116, USA. dac10@utah.edu

Lab on a Chip
|March 10, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated Flushing System for Post-Processing in Microfluidic Device Fabrication.

Micromachines·2026
Same author

Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma.

Frontiers in oncology·2026
Same author

Correction: Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma.

Frontiers in oncology·2026
Same author

Effect of Key Operating Parameters on the Retention and Separation of Ions Using Cyclical Electrical Field Flow Fractionation.

Analytical chemistry·2025
Same author

An implantable, intracerebral osmotic pump for convection-enhanced drug delivery in glioblastoma multiforme.

Frontiers in oncology·2025
Same author

Design and Fabrication of a Cyclical Electrical Field-Flow Fractionation for Differential Retention of Ions.

Analytical chemistry·2025
Same journal

Tunable self-assembling cellular microarray for single-neutrophil vital and suicidal extracellular traps.

Lab on a chip·2026
Same journal

Precise programmable tumor cell subpopulation sorting <i>via</i> an electromagnetic microfluidic platform.

Lab on a chip·2026
Same journal

Bridging dimensions: combining one- and two-photon 3D printing for microfluidic device fabrication.

Lab on a chip·2026
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
See all related articles

This study presents a novel optical biochemical sensor for dissolved oxygen detection. The sensor utilizes a ruthenium dye immobilized on a polymer waveguide, offering a simple, rapid, and flexible design with high sensitivity.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Integrated optical sensors offer miniaturization and high sensitivity for biochemical analysis.
  • Fluorescent dyes are widely used for sensing applications due to their responsiveness to environmental changes.
  • Polymeric waveguides provide a versatile platform for fabricating optical devices.

Purpose of the Study:

  • To design and fabricate an integrated optical biochemical sensor for dissolved oxygen.
  • To immobilize an oxygen-sensitive fluorescent dye onto a polymeric waveguide.
  • To evaluate the sensor's performance in terms of linearity, sensitivity, and fabrication simplicity.

Main Methods:

  • Fabrication of polymeric waveguides on a glass substrate using SU-8.

Related Experiment Videos

  • Immobilization of tris(2,2'-bipyridyl) dichlororuthenium(ii) hexahydrate dye onto the waveguide surface via spin-coating and layer-by-layer assembly.
  • Chemical modification of the SU-8 waveguide for enhanced dye adhesion.
  • Integration of a fluid channel for analyte exposure and evanescent wave interaction.

    • Main Results:

    • The sensor demonstrated a linear response to dissolved oxygen over a wide concentration range.
    • A sensitivity of 0.6 ppm was achieved for dissolved oxygen detection.
    • The fabrication process was found to be simple, rapid, and flexible.

    Conclusions:

    • The developed integrated optical sensor is a promising tool for dissolved oxygen monitoring.
    • The sensor's design offers a balance of functionality, flexibility, and ease of fabrication.
    • This approach can be extended to other biochemical sensing applications.