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Related Experiment Videos

Olfactory bulb neurons express functional, entrainable circadian rhythms.

Daniel Granados-Fuentes1, Meera T Saxena, Laura M Prolo

  • 1Department of Biology, Box 1137, Washington University, St Louis, MO 63130-4899, USA.

The European Journal of Neuroscience
|March 11, 2004
PubMed
Summary

The main olfactory bulb in rats contains neurons that exhibit circadian rhythms. However, these rhythms are not essential for daily locomotion patterns, suggesting roles beyond the canonical circadian system.

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Molecular Biology

Background:

  • Circadian pacemakers regulate daily rhythms in molecular, physiological, and behavioral processes.
  • The role of the main olfactory bulb (MOB) in circadian regulation remains largely unexplored.

Purpose of the Study:

  • To investigate whether the MOB functions as a circadian pacemaker in rats.
  • To determine if MOB-generated circadian rhythms are essential for locomotion.

Main Methods:

  • Long-term multielectrode recordings of cultured rat MOB neurons.
  • Real-time recordings of Period1 gene activity in MOB cells.
  • Assessment of MOB's effect on running wheel behavior after surgical removal.

Main Results:

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  • Individual MOB neurons exhibited near 24-hour oscillations in firing rate.
  • Synchronized circadian rhythmicity was observed in a MOB cell population from embryonic day 19.
  • This rhythmicity was intrinsic to the mitral cell layer, temperature-compensated, and entrainable to temperature cycles.
  • Olfactory bulb removal did not affect running wheel behavior.

Conclusions:

  • Mitral/tufted cells in the MOB are intrinsically capable of circadian pacemaking.
  • MOB circadian rhythms are not required for locomotion, indicating involvement in non-canonical circadian processes.