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Related Experiment Video

Updated: Jun 23, 2026

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord
08:26

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Published on: May 14, 2015

Isolation of postnatal human neural stem cells.

Daniel Dan Liu, Anna E Eastman, Nicole L Womack-Gambrel

    Biorxiv : the Preprint Server for Biology
    |June 22, 2026
    PubMed
    Summary

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    The human brain generates new neurons after birth. Researchers identified two distinct types of postnatal neural stem cells (NSCs) and characterized their differentiation, offering insights into brain development and aging.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Stem Cell Research

    Background:

    • Neurogenesis, the generation of new neurons, was previously thought to cease at birth.
    • Postnatal neurogenesis occurs in the human brain, but the progenitor cells, postnatal neural stem cells (NSCs), are poorly understood.

    Purpose of the Study:

    • To identify and characterize distinct subsets of postnatal human neural stem cells (NSCs).
    • To investigate the differentiation potential and lifespan dynamics of these identified NSC populations.

    Main Methods:

    • Utilized index sorting for prospective isolation of human postnatal NSCs.
    • Employed clonal barcoding and in vivo xenotransplantation to analyze NSC differentiation dynamics.
    • Profiled NSC frequencies across the human lifespan.

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    Isolation and Culture of Embryonic Mouse Neural Stem Cells
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    Isolation and Culture of Embryonic Mouse Neural Stem Cells

    Published on: November 11, 2018

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    Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells

    Published on: January 28, 2015

    Related Experiment Videos

    Last Updated: Jun 23, 2026

    Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord
    08:26

    Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

    Published on: May 14, 2015

    Isolation and Culture of Embryonic Mouse Neural Stem Cells
    09:04

    Isolation and Culture of Embryonic Mouse Neural Stem Cells

    Published on: November 11, 2018

    Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells
    12:06

    Direct Induction of Human Neural Stem Cells from Peripheral Blood Hematopoietic Progenitor Cells

    Published on: January 28, 2015

    Main Results:

    • Identified two NSC subsets: A2B5+ EGFR+ (NINO) biased towards interneuron and oligodendrocyte fates, and A2B5- EGFRhi (NAC) biased towards astrocyte fates.
    • Demonstrated that NSC frequency declines exponentially in the first two decades of life, then stabilizes, with cells present in individuals up to 90 years old.

    Conclusions:

    • Provides a framework for studying postnatal human NSCs.
    • Highlights the potential roles of these NSCs in human development, aging, and neurological diseases.