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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Maternal diclofenac sodium ingestion and severe neonatal pulmonary hypertension

K L Siu1, W H Lee

  • 1Department of Paediatrics, Queen Elizabeth Hospital, Kowloon, Hong Kong, China. kiuloksiu@netscape.net

Journal of Paediatrics and Child Health
|March 11, 2004
PubMed

We describe a case of severe pulmonary hypertension and transient right-sided hypertrophic cardiomyopathy in a neonate, caused by premature closure of ductus arteriosus after short-term maternal use of diclofenac sodium (Voltaren). In view of this associated complication, diclofenac sodium should be avoided during pregnancy. In addition, maternal diclofenac sodium ingestion should be suspected if a newborn develops severe pulmonary hypertension and/or right-sided hypertrophic cardiomyoptathy with closed ductus arteriosus.

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