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Pediatric transplantation of the kidney, liver and heart: summary report
Richard N Fine1, Estella M Alonso, Janet E Fischel
1Department of Pediatrics, Stony Brook Health Sciences Center, State University of New York at Stony Brook, NY, USA.
Insights
This review of pediatric transplant literature (1966-2001) highlights significant gaps in understanding cognitive and psychosocial development. Methodological improvements are recommended for future pediatric transplant research.
Area of Science:
- Pediatric Transplantation
- Child Development
- Medical Literature Review
Background:
- Extensive literature review (1966-2001) focused on pediatric organ transplantation.
- Assessed studies for clinical relevance, reliability, and generalizability.
- Identified methodological deficiencies in existing research.
Purpose of the Study:
- To review growth and development in children post-kidney, liver, and heart transplant.
- To emphasize cognitive and psychosocial development research.
- To provide methodological recommendations for future studies.
Main Methods:
- Comprehensive literature search and critical appraisal of studies.
- Evaluation criteria included study design, sample size, and data consistency.
- Focused on cognitive and psychosocial development due to limited research.
Main Results:
- Growth studies were included, but cognitive and psychosocial development were primary focus.
- Significant methodological limitations were found in developmental research.
- Inconsistencies and deficiencies noted in study designs and data collection.
Conclusions:
- Current research on pediatric transplant recipients' cognitive and psychosocial development is limited.
- Methodological improvements are crucial for future research.
- Recommendations provided for enhancing the quality and reliability of future studies.
Abstract:
The following is a summary report of an extensive review of the literature from 1966 to 2001 on growth and development in children receiving kidney, liver and heart transplants. The literature was assessed for relevancy to current clinical practice and for reliability and generalizability of the inferences based on the study design, controls, sample size, age distribution, confounding factors, use of standardized instruments, and consistency with other findings. While studies on growth are included in the review, the main emphasis is on research in cognitive and psychosocial development since these areas have been far less thoroughly studied and contain various methodological deficiencies. On the basis of the literature review both general methodological recommendations and specific recommendations for future research studies are made. Access to the full is provided on the World Wide Web at http://light.emmes.com/pedstransplantation/.
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