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Vesicles in haptotaxis with hydrodynamical dissipation.

I Cantat1, K Kassner, C Misbah

  • 1Laboratoire de Spectrométrie Physique, Université Joseph Fourier (CNRS), Grenoble I, BP 87, Saint-Martin d'Hères, 38402 France. isabelle.cantat@univ-rennes1.fr

The European Physical Journal. E, Soft Matter
|March 11, 2004
PubMed
Summary

This study analyzes vesicle migration in haptotaxis, revealing two distinct migration regimes. A new migration law differing from Stokes law is identified in the flask regime.

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Area of Science:

  • Biophysics
  • Fluid Dynamics
  • Cell Migration

Background:

  • Vesicle migration is crucial in biological processes like chemotaxis and haptotaxis.
  • Previous analyses have been limited in scope, necessitating a more comprehensive study.

Purpose of the Study:

  • To extensively analyze vesicle migration under adhesion gradients (haptotaxis).
  • To develop and validate new migration laws for different vesicle behaviors.
  • To explore the influence of arbitrary shape evolution on migration dynamics.

Main Methods:

  • Utilized a boundary integral formulation based on the Oseen tensor for analysis.
  • Conducted numerical analysis focusing on 2D flows.
  • Developed general arguments for extracting analytical migration laws.

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Main Results:

  • Identified two distinct migration regimes: the tense (droplet-like) and the flask regime.
  • The tense regime follows Stokes law, while the flask regime exhibits a novel migration law.
  • Analytical laws derived show good agreement with full numerical simulations.

Conclusions:

  • Vesicle migration dynamics are regime-dependent, with distinct laws governing different shapes.
  • The flask regime presents a significant deviation from established Stokesian migration.
  • Further research is needed to address future issues and open questions in vesicle dynamics.