Related Experiment Video

Updated: Aug 25, 2026

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat
06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

Simple estimation of the glomerular filtration rate in sick Thai children

Prayong Vachvanichsanong1, Pirun Saeteu, Alan Geater

  • 1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand. Vprayong@ratree.psu.ac.th

Nephrology (Carlton, Vic.)
|March 12, 2004
PubMed

Insights

This study developed a new formula to accurately estimate creatinine clearance (CCr) in sick Thai children, finding the modified Schwartz formula with a coefficient of 0.465 is more suitable than the original. This improves renal function assessment in pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Clinical Chemistry
  • Biostatistics

Background:

  • Accurate estimation of creatinine clearance (CCr) is crucial for managing pediatric kidney diseases.
  • Existing formulas, like the Schwartz formula, may require validation in diverse populations.
  • Sick children present unique physiological challenges affecting renal function parameters.

Purpose of the Study:

  • To establish an appropriate formula for estimating CCr in sick Thai children.
  • To evaluate the accuracy of the established formula against the Schwartz formula.
  • To refine pediatric renal function assessment in a specific ethnic group.

Main Methods:

  • Studied 160 children (0-19 years) with stable renal function.
  • Collected data on height, weight, urine volume, urine flow, and plasma/urine creatinine concentrations.
  • Calculated CCr using a standard formula and compared it with the Schwartz formula using bootstrap statistics.

Main Results:

  • A linear regression model showed a strong fit for CCr estimation: 0.465 x (Height/Plasma Creatinine).
  • The new coefficient (0.465) was significantly different from the Schwartz formula coefficient (0.55) for children aged ≥1 year (P < 0.00005).
  • No significant age or sex effect was observed on the CCr estimation relationship.

Conclusions:

  • A modified Schwartz formula with a coefficient of 0.465 is recommended for estimating CCr in sick Thai children.
  • This tailored formula offers improved accuracy for renal function assessment in this population.
  • The findings highlight the importance of population-specific adjustments for pediatric renal function estimations.

More Related Videos

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets07:41

Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets

Published on: September 13, 2022

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Renal Clearance01:23

Renal Clearance

The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.