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Placental Assessment Using Microvascular Flow Imaging: Reference Ranges and Clinical Application.

Manaphat Suksai¹, Alan Geater², Thitima Suntharasaj¹

¹Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine

|June 27, 2026

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This summary is machine-generated.

New reference ranges for intraplacental vascularity (VI^MV) were established using ultrasound. VI^MV changes with gestational age and placental location, potentially aiding in assessing placental function.

Area of Science:

Perinatology
Medical Imaging
Vascular Biology

Background:

Accurate assessment of placental vascularity is crucial for monitoring fetal well-being.
Microvascularity-flow ultrasound software (VI^MV) offers a quantitative measure of placental perfusion.
Establishing normative data is essential for clinical interpretation of VI^MV.

Purpose of the Study:

To define gestational age-specific reference ranges for intraplacental VI^MV.
To investigate the influence of placental location, parity, and pregnancy outcomes on VI^MV.
To explore the relationship between VI^MV and other Doppler parameters.

Main Methods:

Prospective study of 354 singleton pregnancies; 243 uncomplicated cases used for reference ranges.

Keywords:

Doppler MV‐Flow intraplacental vascular index placenta ultrasound vascularization

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VI^MV values were analyzed using a residual bootstrap method with 500 iterations.

Quantile regression assessed group differences; associations with Doppler parameters were examined.

Main Results:

VI^MV demonstrated a significant increase with gestational age, with a slight late-gestation decrease.
Anterior placentas showed significantly higher VI^MV from 31 weeks onward compared to posterior placentas.
VI^MV was inversely associated with uterine/umbilical artery pulsatility indices and positively with umbilical vein velocity.

Conclusions:

Gestational age-specific reference ranges for VI^MV were successfully established.
VI^MV shows variations based on placental location and gestational age.
VI^MV may serve as a quantitative marker for placental vascular adaptation and perfusion assessment.