Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO
Elizabeth Joshi1, Mahendra D Chordia, Timothy L Macdonald
1Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.
Bioorganic & Medicinal Chemistry Letters
|March 12, 2004
Abstract:
Solutions of 2-amino-3-aroyl-4,5-dialkylthiophenes in DMSO (dimethyl sulfoxide) undergo regioselective oxidation of benzylic carbon under mild conditions. We describe three examples and propose a mechanism for oxidation.
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