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Comparative study of morphine diffusion from sustained release polymeric suspensions.

M E Morales1, V Gallardo Lara, A C Calpena

  • 1Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Granada, 18071 Granada, Spain.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 12, 2004
PubMed
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This study developed a sustained-release oral morphine suspension using ethylcellulose microparticles. The novel formulation effectively encapsulates morphine, providing controlled drug release over 24 hours for improved patient quality of life.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Polymer Chemistry

Background:

  • Drug delivery systems are crucial for optimizing therapeutic efficacy and patient compliance.
  • Polymeric excipients are widely investigated for developing controlled-release pharmaceutical formulations.
  • Ethylcellulose is a promising polymer for creating sustained-release drug delivery systems.

Purpose of the Study:

  • To design and evaluate an oral sustained-release morphine suspension using ethylcellulose.
  • To compare two methods of drug incorporation into ethylcellulose microparticles: during synthesis (A) versus post-synthesis adsorption (B).
  • To assess the drug encapsulation efficiency and release kinetics of the developed formulations.

Main Methods:

  • Preparation of two types of ethylcellulose suspensions with morphine: suspension A (drug incorporated during synthesis) and suspension B (drug adsorbed post-synthesis).

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  • Quantification of drug encapsulation using spectrophotometry.
  • Evaluation of drug release profiles using Franz-cells and kinetic modeling (Weibull model).

    • Main Results:

    • Suspension A achieved approximately 92% drug encapsulation, while suspension B showed only 15% adsorption.
    • Suspension A demonstrated controlled release of morphine hydrochloride over 24 hours.
    • The release kinetics followed a Weibull model, indicating predictable drug diffusion.

    Conclusions:

    • Ethylcellulose microparticles prepared with in-situ drug incorporation (suspension A) are highly effective for sustained-release oral morphine delivery.
    • This formulation offers precise control over drug release rates, potentially reducing dosing frequency.
    • The developed morphine oral suspension enhances patient quality of life through improved therapeutic management.