Related Experiment Video
Updated: Jun 12, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
C-reactive protein as a predictor of complicated acute cholecystitis: A cohort study
G Renau1, D Abelló1, F Sabench2
1Servicio de Cirugía General y Digestiva, Hospital Universitario Sant Joan de Reus, Reus (Tarragona), Spain.
Introduction:
The Tokyo Guidelines for the severity classification of acute cholecystitis (AC) include leukocytosis as a severity classifier, without considering C-reactive protein (CRP). Our aim was to determine which of the two variables has a greater predictive capacity for local complications in AC (LCAC).
Material And Methods:
A retrospective single-center study was conducted on patients that underwent emergency cholecystectomy within the time frame of June 2022 and December 2023. The variables associated with LCAC were analyzed and an ROC analysis was carried out.
Results:
The multivariate analysis of 145 patients identified the following associations with LCAC: CRP (p < 0.001; OR 11.8), AUC of 0.88 (p = 0.029), and cutoff point of 4 mg/dl (88% sensitivity, 71% specificity); leukocytosis (p < 0.031; OR 5), AUC of 0.81(p = 0.037), and cutoff point of 11.09 x 109/l (78% sensitivity, 70% specificity).
Conclusions:
CRP may have a higher predictive capacity for LCAC than leukocytosis.
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Coronary Syndrome III: Diagnostic studies
Acute Pancreatitis II: Clinical Manifestations and Management
Pericarditis II: Clinical features and Diagnostic Tests
Chronic Pancreatitis II: Collaborative Care
Assessment:
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

