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Updated: Aug 25, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
New therapies for chronic obstructive pulmonary disease
Ganesh Krishna1, Viji Sankaranarayanan, Rajinder K Chitkara
1Division of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Abstract:
Chronic obstructive pulmonary disease (COPD) is the most common lung disease, carrying a significant mortality and morbidity. None of the therapeutic interventions currently available alter the progression of the disease. As our understanding of the basic mechanisms of alveolar destruction and airflow limitation improves, new targets are identified that may eventually result in treatment options which will affect the progression of this disease. In this review, we discuss some of the novel therapeutic options recently developed that may have an impact on the management of COPD. Future directions in research and development of pharmacological agents based on improved understanding of COPD are also discussed.
Insights
Novel treatments for chronic obstructive pulmonary disease (COPD) are emerging. This review explores new therapeutic options and future research directions to potentially alter COPD progression and improve patient outcomes.
Area of Science:
- Pulmonary Medicine
- Pharmacology
Background:
- Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability worldwide.
- Current treatments do not halt the disease's progression.
Purpose of the Study:
- To review novel therapeutic options for COPD management.
- To discuss future research directions in COPD pharmacotherapy.
Main Methods:
- Literature review of recent advancements in COPD therapeutics.
- Analysis of emerging pharmacological targets and strategies.
Main Results:
- Identification of several novel therapeutic approaches for COPD.
- Discussion of potential disease-modifying treatments.
Conclusions:
- Emerging therapies offer promise for altering COPD progression.
- Continued research into COPD mechanisms is crucial for developing effective treatments.
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