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Updated: Aug 25, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
The heart in systemic sclerosis
1Georgetown University, 3800 Reservoir Road, LL Gorman, Washington, DC 20007, USA. steenv@georgetown.edu
Insights
Scleroderma frequently causes heart problems, including asymptomatic cardiac abnormalities and diastolic dysfunction. Early detection and management are crucial for these serious heart complications.
Area of Science:
- Cardiology
- Rheumatology
- Internal Medicine
Background:
- Scleroderma significantly impacts the heart, leading to myocardial, conduction, and pericardial diseases.
- Secondary cardiac dysfunction arises from scleroderma renal crisis and pulmonary hypertension.
- Understanding scleroderma's cardiac manifestations is critical for patient outcomes.
Purpose of the Study:
- To summarize recent advancements in understanding cardiac abnormalities in scleroderma.
- To explore the mechanisms behind heart issues in scleroderma patients.
- To highlight the role of new cardiac technologies in detecting these abnormalities.
Main Methods:
- Review of recent literature on scleroderma and cardiac involvement.
- Analysis of findings from new cardiac imaging and diagnostic technologies.
- Evaluation of studies on diastolic dysfunction and conduction abnormalities.
Main Results:
- New cardiac technologies reveal frequent asymptomatic cardiac abnormalities in scleroderma.
- Diastolic dysfunction is increasingly recognized as common in scleroderma.
- Conduction abnormalities and arrhythmias are significant, life-threatening complications.
Conclusions:
- Scleroderma frequently affects the heart, often asymptomatically.
- Further long-term studies are needed to guide treatment strategies.
- Advanced diagnostics and therapies are improving management of cardiac complications.
Abstract:
The heart is one of the major organs involved in scleroderma. Cardiac involvement can be manifested by myocardial disease, conduction system abnormalities, arrhythmias, or pericardial disease. Additionally, scleroderma renal crisis and pulmonary hypertension lead to significant cardiac dysfunction secondary to damage in the kidney and lung. This report summarizes the recent advances to further understand the types and mechanism of abnormalities in the heart in scleroderma. New cardiac technology shows significant frequencies of asymptomatic cardiac abnormalities. Further long-term studies are necessary to determine the outcome and the best approach to treatment of such abnormalities. Diastolic dysfunction has been carefully evaluated in scleroderma in recent years and appears to be more common than once realized. There is controversy as to whether this is a significant finding independent to other cardiopulmonary problems. More extensive evaluation of the conduction and the arrhythmia ablative therapy has helped manage these life-threatening complications.
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