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Related Experiment Videos

Variation in breast cancer counts using SEER and IARC multiple primary coding rules.

Joellyn L Hotes1, Larry F Ellison, Holly L Howe

  • 1North American Association of Central Cancer Registries, 2021 West White Oaks Drive, Springfield, IL 62704, USA. jhotes@naaccr.org

Cancer Causes & Control : CCC
|March 16, 2004
PubMed
Summary

Breast cancer case counts vary based on the coding rules used. The International Agency for Research on Cancer (IARC) rules yielded 2.4% fewer cases than the Surveillance, Epidemiology, and End Results (SEER) program rules.

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Area of Science:

  • Oncology
  • Cancer Epidemiology
  • Biostatistics

Background:

  • Accurate cancer case counts are crucial for epidemiological studies and resource allocation.
  • Different international and national coding systems may lead to variations in reported cancer incidence.

Purpose of the Study:

  • To compare breast cancer case counts derived from the Surveillance, Epidemiology, and End Results (SEER) program and International Agency for Research on Cancer (IARC) multiple primary coding rules.
  • To identify and quantify differences in case counts based on demographic and clinical factors.

Main Methods:

  • Applied both SEER and IARC multiple primary coding rules to a North American cancer registry dataset (1994-1998).
  • Included only high-quality data registries with obtained permission.

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  • Calculated percentage differences in case counts, using IARC counts as the baseline.

    • Main Results:

    • The IARC rules resulted in 2.4% fewer breast cancer cases compared to SEER rules.
    • Notable percentage differences were observed across age groups (e.g., 80-84 year-olds), histology (e.g., inflammatory breast cancer), and stage at diagnosis (e.g., distant) for both females and males.
    • Differences were generally consistent regardless of laterality.

    Conclusions:

    • Breast cancer case ascertainment is significantly influenced by the specific multiple primary coding rules employed.
    • Standardization of coding rules may be necessary for consistent international cancer surveillance and research.