[Clinical and epidemiological features of uveitis in children]

The structure, dynamic morbidity and clinical specificity of endogenous uveitis have been studied in different-age children in a Moscow district for as long as 30 years. The frequency of uveitis was determined for Moscow; it went up in the city, during the recent 15 years, 5-fold. On the basis of complex examinations of 1573 children with uveitis, the age-related, clinical-and-morphological and etiological specific features of uveitis were investigated. The rate and nature of complications after uveitis leading to the disablement due to blindness and poor vision were defined. Lipid peroxidation, body antioxidant protection, corticosterones and hydrocortisones as well as metabolism of acid glycosaminoglycans were found, according to biochemistry results, to be important in uveitis pathogenesis, which is a fundamental in working out the pathogenetic therapy and prognostication of uveitis. The thus elaborated system of clinical-and-laboratory and of therapeutic measures enhanced the efficiency of the early and differential diagnostics of uveitis and of the complex therapeutic treatment of the discussed severe pathology, which brought about a 2-fold cut of stay in hospital, improved the functional outcomes and reduced the complications' rate.