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Epiphyseal osteoblastoma of tibia with xanthomatous stromal reaction
Xinmin Zhang1, Susan V Bukata, John H Healey
1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Abstract:
Osteoblastoma occurring in long bones has a distinctive predilection for the metaphysis and the diaphysis. Epiphyseal location is rare. Although variation in histologic patterns is a well-known feature of this tumor, xanthomatous stromal reaction has not yet been described. We report a case of a 34-year-old man who developed an osteoblastoma primarily located in the epiphysis of his left tibia with extension into the metaphysis. The striking histologic features included a prominent xanthoma-like stroma consisting of foamy histiocytes in addition to focal areas with classical configuration of an osteoblastoma. The significance of this finding is discussed.
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