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SARS: prognosis, outcome and sequelae.

K S Chan1, J P Zheng, Y W Mok

  • 1United Christian Hospital, Hong Kong, SAR, China. chanks@ha.org.hk

Respirology (Carlton, Vic.)
|March 17, 2004
PubMed
Summary
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Severe acute respiratory syndrome (SARS) can cause significant illness and death. Long-term health issues, including lung problems and psychological distress, may persist after recovery, requiring ongoing patient monitoring.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Public Health

Background:

  • Severe acute respiratory syndrome (SARS) presents significant morbidity and mortality.
  • Prognostic factors like age and comorbidities are known, but viral and host factors' impact remains unclear.
  • Limited data exists on the long-term health consequences (sequelae) following SARS recovery.

Purpose of the Study:

  • To review and summarize the known and potential long-term sequelae of SARS.
  • To highlight the need for continued follow-up of SARS survivors.
  • To inform management strategies for persistent or emerging health issues.

Main Methods:

  • Review of published literature on SARS clinical outcomes and follow-up studies.
  • Analysis of reported radiological, functional, and psychological abnormalities post-SARS.

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  • Identification of potential complications such as pulmonary fibrosis and avascular necrosis.

    • Main Results:

    • Survivors may experience varying degrees of radiological, functional (weakness, shortness of breath), and psychological abnormalities.
    • Pulmonary fibrosis, restrictive lung patterns, and decreased carbon monoxide diffusing capacity are reported.
    • Anxiety, depression, and avascular necrosis of the hip are noted complications, with most psychological issues improving over time.

    Conclusions:

    • While some SARS sequelae may improve, long-term effects are not fully understood.
    • Continued patient follow-up is crucial for managing persistent or emerging physical, psychological, and social issues.
    • Further research is needed to fully characterize the long-term impact of SARS.