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Related Experiment Videos

Diffusion MRI findings in phenylketonuria.

R N Sener1

  • 1Department of Radiology, Ege University Hospital, 35100 Bornova, Izmir, Turkey. rnsener@med.ege.edu.tr

European Radiology
|March 17, 2004
PubMed
Summary

Diffusion MRI revealed two distinct patterns in phenylketonuria patients: restricted diffusion with low apparent diffusion coefficient (ADC) values and increased diffusion with high ADC values.

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Area of Science:

  • Neuroimaging
  • Metabolic Disorders

Background:

  • Phenylketonuria (PKU) is an inborn error of metabolism requiring early dietary intervention.
  • Mentally normal PKU patients under long-term dietary control were selected for this study.

Observation:

  • Diffusion MRI was performed using spin-echo, echo-planar imaging at 1.5 T.
  • Heavily diffusion-weighted (b=1000 mm2/s) images and apparent diffusion coefficient (ADC) values were analyzed.

Findings:

  • Two distinct diffusion patterns were observed: restricted diffusion (low ADC: 0.46-0.57x10(-3) mm2/s) and increased diffusion (high ADC: 1.37-1.63x10(-3) mm2/s).
  • Restricted diffusion showed high signal on b=1000 images, while increased diffusion showed normal signal.

Implications:

  • These diffusion patterns may represent different histopathological changes in PKU.
  • Alternatively, the findings could indicate varying stages of the same underlying disease process in PKU.

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