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Spectroscopic investigation of interactions between dipeptides and vanadate(V) in solution
Olivier Durupthy1, Aurélie Coupé, Lawrence Tache
1Laboratoire Chimie de la Matière Condensée, UMR CNRS 7574, Tour 54 E5, Université Pierre et Marie Curie (Paris 6), 4 place Jussieu, 75252 Paris Cedex 05, France.
Abstract:
The reaction of vanadate(V) with a series of dipeptides (Val-Gln, Ala-Gln, Gly-Gln, Gly-Glu, and Ala-Gly) was investigated by UV-visible spectroscopy and multinuclear ((51)V, (14)N, (13)C) NMR spectroscopy in solution. It was possible to evaluate the formation constants of the corresponding complexes for which a molecular structure was proposed. Complex formation is favored by the presence of a functionalized or a sterically demanding side chain. The Val-Gln dipeptide which combines both properties exhibits one of the highest formation constant reported so far for dipeptides.