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Avellino corneal dystrophy after LASIK.

Roo Min Jun¹, Hungwon Tchah, Tae-im Kim

¹Department of Ophthalmology, Ewha Womans University College of Medicine, Seoul, South Korea.

|March 17, 2004

Summary

Laser in situ keratomileusis (LASIK) surgery can worsen Avellino corneal dystrophy (ACD) by increasing corneal opacities. Mechanical removal of deposits is ineffective, but mitomycin C may help.

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Area of Science:

Ophthalmology
Corneal Diseases
Refractive Surgery

Background:

Avellino corneal dystrophy (ACD) is a genetic condition causing corneal opacities.
Laser in situ keratomileusis (LASIK) is a common refractive surgery for myopia.

Observation:

LASIK surgery exacerbated granular corneal deposits in patients with ACD.
Corneal opacities appeared 12 months or more post-LASIK.
Visual acuity decreased with increased opacity density.

Findings:

All ACD patients studied were heterozygous for the ACD gene.
Mechanical removal of interface deposits led to recurrence in one patient.
Phototherapeutic keratectomy (PTK) with mitomycin C showed potential in preventing recurrence.

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Implications:

LASIK is contraindicated in patients with ACD due to worsening corneal opacities.
Surgical removal of deposits alone is insufficient to prevent recurrence.
Mitomycin C combined with surgical removal may offer a treatment option for post-LASIK ACD exacerbations.