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Related Experiment Videos

Selection, subdivision and extinction and recolonization.

Joshua L Cherry1

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. jcherry@ncbi.nlm.nih.gov

Genetics
|March 17, 2004
PubMed
Summary
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Local extinction and recolonization in populations reduce the effectiveness of natural selection. This process alters allele frequency dynamics, making it harder for advantageous alleles to fix and easier for deleterious ones.

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Ecological dynamics

Background:

  • Natural selection and genetic drift interact to shape allele frequencies.
  • Subdivided populations experience local extinction and recolonization, adding stochasticity.
  • These metapopulation dynamics can influence evolutionary trajectories.

Purpose of the Study:

  • To investigate how local extinction and recolonization affect natural selection.
  • To analyze the impact of metapopulation dynamics on allele frequency change.
  • To understand the interplay between selection, drift, and extinction-recolonization cycles.

Main Methods:

  • Theoretical modeling of subdivided populations with extinction and recolonization.
  • Analysis of scenarios with multiple, variable, or unequal founding alleles.

Related Experiment Videos

  • Inclusion of dominance and local frequency dependence.
  • Computer simulations to validate theoretical predictions.

    • Main Results:

    • Extinction-recolonization events diminish the relative importance of natural selection.
    • The effective population size and selection coefficient product (N(e)s(e)) is reduced.
    • Deleterious alleles show increased fixation probability, while advantageous alleles show decreased probability.
    • Dominance and frequency dependence effects are altered by metapopulation dynamics.

    Conclusions:

    • Metapopulation dynamics provide an additional source of stochasticity, impacting selection.
    • The behavior of selected alleles in subdivided populations can be approximated by models of unstructured populations with modified parameters.
    • Extinction and recolonization generally reduce the efficacy of selection, favoring fixation of deleterious alleles.