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Antioxidative constituents from Lycopus lucidus.

Eun-Rhan Woo1, Mei Shan Piao

  • 1College of Pharmacy, Chosun University, Gwangju 501-759, Korea. wooer@chosun.ac.kr

Archives of Pharmacal Research
|March 17, 2004
PubMed
Summary

Five compounds, including rosmarinic acid and luteolin derivatives, were isolated from Lycopus lucidus. These compounds demonstrated significant antioxidative activity in NBT superoxide scavenging assays, with notable potency observed.

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products

Background:

  • Lycopus lucidus (Labiatae) is a plant with potential medicinal properties.
  • Phenolic compounds and flavonoids are known for their biological activities.

Purpose of the Study:

  • To isolate and identify compounds from the aerial parts of Lycopus lucidus.
  • To evaluate the antioxidative activity of the isolated compounds.

Main Methods:

  • Isolation of compounds using chemical and spectral analysis.
  • Assessment of antioxidative activity via the NBT superoxide scavenging assay.

Main Results:

  • Five compounds were isolated: three phenolic compounds (rosmarinic acid, methyl rosmarinate, ethyl rosmarinate) and two flavonoids (luteolin, luteolin-7-O-beta-D-glucuronide methyl ester).
  • All five compounds exhibited potent antioxidative activity.
  • IC50 values ranged from 0.78 to 3.05 microg/mL, with ethyl rosmarinate showing the highest potency.

Conclusions:

  • Lycopus lucidus is a source of potent antioxidative phenolic compounds and flavonoids.
  • The isolated compounds, particularly ethyl rosmarinate, show promise for applications requiring antioxidant properties.

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