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[Hepatitis C virus infection in renal-transplant patients]

N Kamar1, J Izopet, D Ribes

  • 1Service de néphrologie, dialyse et transplantation, CHU Toulouse-Rangueil.

Nephrologie
|March 17, 2004
PubMed

Insights

Chronic hepatitis C virus (HCV) infection significantly increases mortality and reduces graft survival in renal transplant patients. Treating HCV-positive dialysis patients with alpha-interferon before transplantation is mandatory.

Area of Science:

  • Nephrology
  • Hepatology
  • Transplantation

Background:

  • Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease post-renal transplantation.
  • HCV infection remains prevalent in dialysis and renal transplant populations, impacting patient outcomes.
  • HCV-positive renal transplant recipients face higher mortality rates, primarily from liver disease and sepsis.

Purpose of the Study:

  • To evaluate the impact of HCV infection on mortality, graft survival, and liver disease progression in renal transplant patients.
  • To assess the role of HCV in de novo glomerulopathy and liver fibrosis in immunosuppressed patients.
  • To determine the optimal management strategy for HCV in patients undergoing renal transplantation.

Main Methods:

  • Review of outcomes in HCV-positive versus HCV-negative renal transplant patients.
  • Analysis of mortality causes and graft survival rates.
  • Investigation of de novo glomerulopathy and liver fibrosis.
  • Evaluation of current treatment protocols for HCV in pre-transplant dialysis patients.

Main Results:

  • HCV-positive renal transplant patients exhibit increased mortality and decreased graft survival.
  • Liver disease and sepsis are identified as primary causes of death in this cohort.
  • De novo glomerulopathy may contribute to reduced graft survival in HCV-infected patients.
  • The effect of HCV on liver fibrosis under immunosuppression requires further investigation.

Conclusions:

  • HCV infection poses significant risks to renal transplant recipients, affecting survival and graft function.
  • Proactive treatment of HCV in dialysis patients awaiting transplantation is crucial.
  • Alpha-interferon therapy for HCV-positive/RNA-positive dialysis patients before transplantation is recommended.

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