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Updated: Jul 28, 2026

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Diagnostic Necropsy and Selected Tissue and Sample Collection in Rats and Mice

Published on: August 7, 2011

Needle necropsy in AIDS.

S Satyanarayana¹, A T Kalghatgi, A K Malaviya

¹Department of Pathology, Base Hospital, Delhi Cantt. sridharasatyam@rediffmail.com

Indian Journal of Pathology & Microbiology

|March 18, 2004

Summary

A novel needle necropsy protocol offers a safe method for diagnosing diseases in HIV-infected cadavers. This minimally invasive technique successfully identified disseminated tuberculosis, cryptococcosis, and other infections.

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Area of Science:

Pathology
Infectious Diseases
Oncology

Background:

Autopsies are crucial for understanding disease progression.
Pathologists face risks performing autopsies on HIV-infected cadavers.
Minimally invasive autopsy methods are needed to mitigate risks.

Purpose of the Study:

To evaluate a low-risk needle necropsy protocol for HIV-infected cadavers.
To assess the diagnostic yield of fine needle aspiration cytology, tru-cut biopsies, and microbiological examination.

Main Methods:

A needle necropsy protocol was developed using fine needle aspiration cytology, tru-cut biopsies, and microbiological examination.
The protocol was applied to 44 HIV-infected cadavers.
Samples were analyzed for infectious agents and malignancies.

Main Results:

The needle necropsy protocol provided diagnoses in all 44 cases.
Disseminated tuberculosis (40.9%) and cryptococcosis (27.2%) were the most common findings.
Poly-microbial infections (27.2%) and non-Hodgkin's lymphoma (9%) were also detected.
Various infectious agents including Histoplasma capsulatum, Isospora belli, Toxoplasma gondii, Candida sp, and Cryptococcus sp were identified.

Conclusions:

Needle necropsy is a viable and effective diagnostic tool for HIV-infected cadavers.
This minimally invasive approach reduces risks to personnel while providing comprehensive diagnostic information.
Limitations include the lack of gross pathology material and potential inaccessibility of deep-seated lesions.