Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Needle necropsy in AIDS.

S Satyanarayana1, A T Kalghatgi, A K Malaviya

  • 1Department of Pathology, Base Hospital, Delhi Cantt. sridharasatyam@rediffmail.com

Indian Journal of Pathology & Microbiology
|March 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A drug-resistant TB cluster in a refugee family with Mendelian susceptibility to mycobacterial disease (MSDM).

IJTLD open·2026
Same author

Zero knowledge verifiable, semi asynchronous federated learning for trajectory prediction on permissioned blockchain.

Scientific reports·2026
Same author

Operational research to End TB: 2<sup>nd</sup> edition of the Union's Guide to operational research.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

Cardiac dysfunction in transfusion-dependent β-thalassaemia: Insights into apolipoprotein E genotypes and iron metrics in a north Indian cohort.

British journal of haematology·2025
Same author

Evaluating disability, comorbidities and risk factors after TB treatment: an 18-24 month follow-up.

IJTLD open·2025
Same author

TB preventive therapy: uptake and time to initiation during implementation of '7-1-7'.

IJTLD open·2024
Same journal

Prof Aseem Kumar Basu, MBBS, DTM and H, FRCPath (Lond), PhD (Lond), Fmr. Professor Department of Haematology, School of Tropical Medicine, Kolkata, India.

Indian journal of pathology & microbiology·2026
Same journal

Beyond the ordinary: Extramedullary hematopoiesis in an ossified psammomatous meningioma.

Indian journal of pathology & microbiology·2026
Same journal

Histomorphological spectrum of Adnexal Tumor with rippled pattern an unusual variant: Report of three cases.

Indian journal of pathology & microbiology·2026
Same journal

The shape-shifter: A case of pleomorphic giant cell carcinoma of prostate.

Indian journal of pathology & microbiology·2026
Same journal

Metachronous renal cell carcinoma with delayed testicular metastasis coexisting with synchronous prostatic adenocarcinoma.

Indian journal of pathology & microbiology·2026
Same journal

Cribriform-morular thyroid carcinoma with nodal metastasis: A diagnostic dilemma.

Indian journal of pathology & microbiology·2026
See all related articles

A novel needle necropsy protocol offers a safe method for diagnosing diseases in HIV-infected cadavers. This minimally invasive technique successfully identified disseminated tuberculosis, cryptococcosis, and other infections.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Oncology

Background:

  • Autopsies are crucial for understanding disease progression.
  • Pathologists face risks performing autopsies on HIV-infected cadavers.
  • Minimally invasive autopsy methods are needed to mitigate risks.

Purpose of the Study:

  • To evaluate a low-risk needle necropsy protocol for HIV-infected cadavers.
  • To assess the diagnostic yield of fine needle aspiration cytology, tru-cut biopsies, and microbiological examination.

Main Methods:

  • A needle necropsy protocol was developed using fine needle aspiration cytology, tru-cut biopsies, and microbiological examination.
  • The protocol was applied to 44 HIV-infected cadavers.
  • Samples were analyzed for infectious agents and malignancies.

Related Experiment Videos

Main Results:

  • The needle necropsy protocol provided diagnoses in all 44 cases.
  • Disseminated tuberculosis (40.9%) and cryptococcosis (27.2%) were the most common findings.
  • Poly-microbial infections (27.2%) and non-Hodgkin's lymphoma (9%) were also detected.
  • Various infectious agents including Histoplasma capsulatum, Isospora belli, Toxoplasma gondii, Candida sp, and Cryptococcus sp were identified.

Conclusions:

  • Needle necropsy is a viable and effective diagnostic tool for HIV-infected cadavers.
  • This minimally invasive approach reduces risks to personnel while providing comprehensive diagnostic information.
  • Limitations include the lack of gross pathology material and potential inaccessibility of deep-seated lesions.