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Published on: June 2, 2015

Venous thrombosis: prevalence of prothrombotic defects in north Indian population

Maitreyee Bhattacharyya1, M Kannan, V P Chaudhry

  • 1Department of Hematology, All India Institute of Medical Sciences, New Delhi.

Indian Journal of Pathology & Microbiology
|March 18, 2004
PubMed

Insights

This study investigated prothrombotic states in 431 thrombosis patients. Acquired or inherited factors were identified in over half, highlighting the importance of comprehensive risk assessment for venous thrombosis.

Area of Science:

  • Hematology
  • Vascular Medicine
  • Genetics

Background:

  • Venous thrombosis is a complex condition with various underlying causes.
  • Identifying prothrombotic states is crucial for effective management and prevention.

Purpose of the Study:

  • To evaluate the prevalence of acquired and inherited prothrombotic states in patients with venous thrombosis.
  • To identify specific risk factors associated with these conditions.

Main Methods:

  • Retrospective analysis of 431 patients diagnosed with venous thrombosis.
  • Assessment for acquired risk factors including liver disease, oral contraceptives, puerperium, malignancy, and lupus anticoagulant.
  • Laboratory testing for deficiencies in Protein C, Protein S, Antithrombin III (AT III), and Activated Protein C Resistance (APC-R).

Main Results:

  • Acquired risk factors were present in 28.7% of patients, and inherited factors in 32.3%.
  • Low Protein C levels (21.1%), Protein S deficiency (19.0%), and AT III deficiency (6.4%) were observed, with significant proportions attributed to acquired causes.
  • Activated Protein C Resistance (APC-R) was detected in 12.5% of cases.

Conclusions:

  • A significant proportion of venous thrombosis cases are associated with identifiable acquired or inherited prothrombotic states.
  • Acquired factors play a substantial role in deficiencies of Protein C, Protein S, and AT III.
  • Further investigation into these prothrombotic states is warranted for improved patient outcomes.

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