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Updated: Aug 25, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

[Relationship between expression of matrix metalloproteinase-9 (MMP-9) and angiogenesis in renal cell carcinoma]

Yao Zhang1, Xiao-Hou Wu, Gui-Hua Cao

  • 1Department of Urology, The First Affiliated Hospital of Chongqing University of Medicine Sciences, Chongqing, 400016, PR China.

AI Zheng = Aizheng = Chinese Journal of Cancer
|March 18, 2004
PubMed
Abstract

Insights

Matrix metalloproteinase-9 (MMP-9) promotes tumor angiogenesis in renal cell carcinoma (RCC). MMP-9 expression correlates with tumor stage and grade, indicating its role in RCC progression and metastasis potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Context:

  • Matrix metalloproteinase-9 (MMP-9) is implicated in tumor invasion, metastasis, and angiogenesis.
  • Renal cell carcinoma (RCC) is a significant malignancy where understanding tumor growth mechanisms is crucial.

Purpose:

  • To investigate the relationship between MMP-9 expression and angiogenesis in RCC.
  • To determine the clinical significance of MMP-9 in RCC progression.

Summary:

  • SP immunohistochemistry analyzed MMP-9, vascular endothelial growth factor (VEGF), and microvessel density (MVD) in 78 RCC tissues.
  • MMP-9 expression correlated with RCC pathological stage and histological grade (P<0.05).
  • MMP-9-positive tissues exhibited significantly higher MVD (110.46±50.16) compared to MMP-9-negative tissues (84.77±44.52) (P<0.05).
  • A positive correlation was found between MMP-9 and VEGF expression intensity (r=0.4096, P<0.01).
  • MMP-9 and VEGF demonstrated a synergistic effect on angiogenesis in RCC.

Impact:

  • MMP-9 is significantly associated with angiogenesis in RCC.
  • MMP-9 can serve as a potential biomarker for predicting RCC invasion and metastasis.
  • Findings contribute to understanding RCC pathogenesis and identifying therapeutic targets.

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