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Possible link between glycated hemoglobin and lipid peroxidation in hyperthyroidism.
K M Mohan Kumar1, Zachariah Bobby, N Selvaraj
1Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India.
Summary
In hyperthyroid patients, elevated glycated hemoglobin (HbA1C) is linked to higher fasting glucose and lipid peroxides. Ascorbic acid and glutathione levels were lower, but not associated with HbA1C.
Area of Science:
- Endocrinology
- Clinical Chemistry
Background:
- Glycated hemoglobin (HbA1C) is influenced by glucose, lipid peroxides, ascorbic acid, and reduced glutathione (GSH).
- Hyperthyroidism can affect metabolic markers, including HbA1C.
Purpose of the Study:
- To investigate the relationships among HbA1C, fasting glucose, lipid peroxides, ascorbic acid, and GSH in hyperthyroid patients.
- To determine factors influencing HbA1C levels in hyperthyroidism.
Main Methods:
- Compared 22 untreated hyperthyroid patients with 17 healthy controls.
- Analyzed whole blood GSH, HbA1C, plasma lipid peroxides, ascorbic acid, and fasting glucose.
- Utilized direct and partial correlation analysis.
Main Results:
- Hyperthyroid patients showed significantly higher HbA1C and lipid peroxides compared to controls.
- Ascorbic acid and GSH levels were significantly lower in hyperthyroid patients.
- Fasting glucose and lipid peroxides positively correlated with HbA1C; ascorbic acid and GSH did not.
Conclusions:
- HbA1C in hyperthyroid patients is closely associated with fasting glucose and lipid peroxides.
- Serum lipid peroxide levels are important to consider when interpreting HbA1C in hyperthyroidism.