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Updated: Aug 25, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Control scale of antibiotic prescriptions in intensive care]

Marie Thuong1, Jean-Ralph Zahar, Yves Cohen

  • 1Service de réanimation polyvalente, Hôpital Delafontaine, Saint-Denis (93).

Presse Medicale (Paris, France : 1983)
|March 18, 2004
PubMed

Insights

Improving antibiotic prescription is crucial for managing bacterial resistance. New guidelines and a control scale were developed to help prescribers optimize antibiotic use in intensive care, reducing mortality and morbidity.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Context:

  • Antibiotic resistance is a major global health threat.
  • Inappropriate antibiotic prescription (PA) occurs in 30-50% of intensive care unit (ICU) patients.
  • Inadequate initial antibiotic therapy increases mortality and morbidity.

Purpose:

  • To improve antibiotic prescription habits in healthcare settings.
  • To develop practical guidelines and a control tool for antibiotic prescription.
  • To address challenges in antibiotic use, including empirical treatment and reassessment.

Summary:

  • A panel of experts convened to discuss and establish guidelines for antibiotic prescription.
  • Key discussion points included empirical treatment, documentation, antibiotic choice, reassessment, combination therapy, and treatment duration.
  • A control scale was developed to aid prescribers in optimizing antibiotic use.

Impact:

  • Aims to reduce the incidence of inappropriate antibiotic prescription in ICUs.
  • Expected to improve patient outcomes by optimizing antibiotic therapy.
  • Contributes to the broader strategy of combating antimicrobial resistance.

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