Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perforated synapses are present during synaptogenesis in rat neocortex.

W Itarat1, D G Jones

  • 1Department of Anatomy, University of Otago, Dunedin, New Zealand.

Synapse (New York, N.Y.)
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Noble gases confirm plume-related mantle degassing beneath Southern Africa.

Nature communications·2023
Same author

Noble gases confirm plume-related mantle degassing beneath Southern Africa.

Nature communications·2019
Same author

Crystalloid resuscitation in trauma patients: deleterious effect of 5L or more in the first 24h.

BMC surgery·2018
Same author

Enhancement: are ethicists excessively influenced by baseless speculations?

Medical humanities·2013
Same author

Exposure of burrowing mammals to 222Rn.

The Science of the total environment·2012
Same author

Chemical signatures of the Anthropocene in the Clyde estuary, UK: sediment-hosted Pb, (207/206)Pb, total petroleum hydrocarbon, polyaromatic hydrocarbon and polychlorinated biphenyl pollution records.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2011
Same journal

LncRNA MIAT Protects Against Sevoflurane-Induced Cognitive Dysfunction in Neonatal Rats via the miR-15b-5p/Ccnd1 Axis.

Synapse (New York, N.Y.)·2026
Same journal

A Survey of Automatic Sleep Staging: Technical Route, Technical Challenges, and Future Perspectives.

Synapse (New York, N.Y.)·2026
Same journal

Structural Architecture and Evolutionary Conservation of Cerebellin-Mediated Trans-Synaptic Signaling.

Synapse (New York, N.Y.)·2026
Same journal

Correction to "Time of Day Does Not Impact Spinal Serotonin Levels in Humans".

Synapse (New York, N.Y.)·2026
Same journal

Effect of Healthy Aging on the Cytoarchitecture of Layer V Pyramidal Neurons in the Motor Cortex of Rats: A Golgi Study.

Synapse (New York, N.Y.)·2026
Same journal

Ketamine Responsiveness of Mice Exhibiting Anorexia-Like Behavior Correlates With Synaptic AMPA Receptor Distribution.

Synapse (New York, N.Y.)·2026
See all related articles

Perforated and nonperforated synapses may be separate populations, not stages of development. This study found perforated synapses present early in synaptogenesis, suggesting distinct developmental paths.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Aging is associated with increased perforated synapse size and number.
  • Previous theories suggested nonperforated synapses enlarge, perforate, and split with age.
  • Recent studies propose perforated and nonperforated synapses are distinct populations.

Purpose of the Study:

  • To investigate the developmental trajectory of perforated synapses.
  • To test the hypothesis that perforated and nonperforated synapses are separate populations.
  • To examine the ultrastructure of synapses during early development.

Main Methods:

  • Ultrastructural analysis of synapses in rat parietal cortex.
  • Serial sectioning and three-dimensional reconstruction of synapses.

Related Experiment Videos

  • Examination of synapses at 19-20 days gestation and 1-4 days postnatal.

    • Main Results:

    • Perforated synapses were observed at all studied developmental ages.
    • Some early perforated synapses showed simple organization.
    • Other developing perforated synapses displayed multiple postsynaptic density (PSD) components.

    Conclusions:

    • Perforated synapses exist early in synaptogenesis.
    • Developing perforated synapses exhibit unique characteristics.
    • Findings support the concept of distinct synaptic populations rather than a single developmental pathway.