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Leukotriene receptor antagonism in experimental acute pancreatitis in rats

Nevin Oruc1, Vahit Yukselen, A Omer Ozutemiz

  • 1Department of Gastroenterology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.

European Journal of Gastroenterology & Hepatology
|March 19, 2004
PubMed
Abstract

Insights

Zafirlukast, a leukotriene receptor antagonist, worsened acute pancreatitis in rats by increasing pancreatic damage. This suggests blocking leukotriene receptors may exacerbate pancreatitis through other inflammatory pathways, requiring further investigation.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Acute pancreatitis involves complex inflammatory pathways.
  • Leukotrienes are implicated as potential mediators in acute pancreatitis.

Purpose of the Study:

  • To investigate the effects of zafirlukast, a leukotriene receptor antagonist, on acute pancreatitis.
  • To explore the relationship between zafirlukast's effects and prostaglandin synthesis in acute pancreatitis.

Main Methods:

  • Acute pancreatitis was induced in rats using cerulein injections.
  • Rats were pretreated with zafirlukast and/or indomethacin to inhibit prostaglandin synthesis.
  • Pancreatic histopathology, serum amylase, and myeloperoxidase activity were assessed.

Main Results:

  • Zafirlukast pretreatment significantly increased pancreatic histopathological scores and fatty necrosis in rats with acute pancreatitis.
  • Inhibition of prostaglandin synthesis partially mitigated the adverse effects of zafirlukast.
  • Zafirlukast alone did not induce pancreatic damage.

Conclusions:

  • Leukotriene receptor antagonism with zafirlukast exacerbates acute pancreatitis in rats.
  • Blocking cysteinyl leukotriene receptors may induce other inflammatory mediator pathways.
  • Further studies are needed to fully understand leukotriene receptor antagonism's pancreatic effects.

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