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Left ventricular thrombosis is associated with increased mean platelet volume in patients with dilated cardiomyopathy

Mehmet Birhan Yilmaz1, Yesim Akin, Senay Funda Biyikoglu

  • 1Yuksek Ihtisas Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey. cardioceptor@ttnet.net.tr

Acta Cardiologica
|March 20, 2004
PubMed

Insights

Mean platelet volume, a marker of platelet reactivity, is significantly higher in patients with dilated cardiomyopathy and left ventricular thrombosis. This finding suggests a potential link requiring further investigation into antiplatelet therapies.

Area of Science:

  • Cardiology
  • Hematology
  • Thrombosis Research

Background:

  • Dilated cardiomyopathy is linked to left ventricular thrombosis, a major cause of peripheral emboli and mortality.
  • Altered hemostasis and platelet behavior are observed in dilated cardiomyopathy patients, even in sinus rhythm.

Purpose of the Study:

  • To investigate the association between mean platelet volume and left ventricular thrombosis in patients with dilated cardiomyopathy.
  • To determine if mean platelet volume can serve as a predictor of left ventricular thrombosis.

Main Methods:

  • Prospective enrollment of 48 consecutive patients with dilated cardiomyopathy and sinus rhythm.
  • Comparison of patients with left ventricular thrombosis against an age-sex-matched control group without left ventricular thrombosis.

Main Results:

  • Patients with left ventricular thrombosis exhibited significantly higher mean platelet volume (9.5 +/- 0.8) compared to controls (8.7 +/- 0.6, p < 0.001).
  • Mean platelet volume is elevated in dilated cardiomyopathy patients with left ventricular thrombosis.

Conclusions:

  • Increased mean platelet volume in dilated cardiomyopathy patients with left ventricular thrombosis may indicate a causal relationship.
  • Further research is warranted to explore the role of antiplatelet agents in preventing and treating left ventricular thrombosis in this population.
Abstract

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