Related Experiment Video
Updated: Aug 15, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Physicochemical characterization and dissolution properties of meloxicam-cyclodextrin binary systems
N Buchi Naidu1, K P R Chowdary, K V R Murthy
1Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India. nbnaid2@email.uky.edu
This study shows that complexing meloxicam (ME) with cyclodextrins (CDs) improves its dissolution properties. The binary systems formed enhanced meloxicam solubility and bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Physical Chemistry
- Materials Science
Background:
- Meloxicam (ME) is a non-steroidal anti-inflammatory drug with limited aqueous solubility.
- Cyclodextrins (CDs) are cyclic oligosaccharides with a hydrophobic cavity and hydrophilic exterior, widely used to enhance the solubility and bioavailability of poorly soluble drugs.
Purpose of the Study:
- To investigate the physicochemical properties of meloxicam-cyclodextrin (ME-CD) binary systems.
- To enhance the dissolution properties of meloxicam through complexation with alpha-, beta-, and gamma-cyclodextrins.
- To characterize the inclusion complex formation in both solution and solid states.
Main Methods:
- Phase solubility analysis
- Mass spectrometry
- 1H Nuclear Magnetic Resonance (NMR) spectroscopy
- Differential Scanning Calorimetry (DSC)
- Powder X-ray diffractometry (PXRD)
- Scanning Electron Microscopy (SEM)
- In vitro dissolution studies
Main Results:
- Solution studies confirmed 1:1 molar complexation of meloxicam with all tested cyclodextrins (alpha-, beta-, and gamma-CD).
- Solid-state studies, particularly with gamma-cyclodextrin, confirmed true inclusion complex formation at 1:1 and 1:2 molar ratios.
- ME-CD binary systems exhibited significantly superior dissolution properties compared to pure meloxicam.
Conclusions:
- Complexation with alpha-, beta-, and gamma-cyclodextrins effectively enhances the dissolution rate of meloxicam.
- The formation of inclusion complexes is confirmed in both solution and solid states, with gamma-cyclodextrin showing notable efficacy.
- These findings suggest that ME-CD binary systems hold promise for improving meloxicam's therapeutic efficacy.
More Related Videos
10:10Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
10:53Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Influencing Drug Absorption: Drug Dissolution
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Drug Dissolution: Requirements and Profile Comparison
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence