Related Experiment Video
Updated: Aug 25, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Helquinoline, a new tetrahydroquinoline antibiotic from Janibacter limosus Hel 1+
Ratnakar N Asolkar1, Dirk Schröder, Rolf Heckmann
1Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Abstract:
The ethyl acetate extract of cultures of Janibacter limosus showed a high biological activity against bacteria, and fungi and delivered two new natural products, a tetrahydroquinoline derivative designated as helquinoline (1), and the N-acetylkynuramine (3a), along with other known secondary metabolites. The structure of 1 has been elucidated as 4-methoxy-2-methyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid on the basis of 1D and 2D NMR and mass spectra. The relative stereochemistry of the compound 1 was assigned as 2R*,4R* with the aid of coupling constants, NOESY correlation and by comparison with a related compound.
More Related Videos
10:24Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells
Published on: May 22, 2026
07:13Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
Published on: August 8, 2025
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Inhibitors of Bacterial DNA Synthesis
Antibiotic Selection
Antiprotozoal Agents
Bacterial Signaling