Related Experiment Videos
Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog
Stefania Bencini1, Mario Migaldi, Giovanni Castagnetti
1Department of Pathologic Anatomy and Forensic Medicine, Section of Pathologic Anatomy, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Annals of the New York Academy of Sciences
|March 23, 2004
Abstract:
This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression, thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.