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Updated: Aug 25, 2026

In vitro Neuromuscular Junction Induced from Human Induced Pluripotent Stem Cells
Published on: December 3, 2020
Transcription in neuromuscular junction formation: who turns on whom?
Morten Sunesen1, Jean-Pierre Changeux
1Laboratoire de Recepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France. msunesen@pasteur.fr
Abstract:
The neuromuscular junction is a particular advantageous synapse to investigate the molecular processes engaged in synaptogenesis. Both the motor nerve and the muscle cell contribute to the patterned distribution of a definite set of membrane proteins into two distinct regions, a sub-synaptic end plate zone and an extra-synaptic region. Accordingly, the transcription of acetylcholine receptors is highly compartmentalized being much higher in the sub-synaptic the in the extra-synaptic region. In this review, we focus on the signaling pathways and the gene expression mechanisms that mediate the enhanced transcription in the sub-synaptic region and the silencing of transcription in extra-synaptic regions.
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Transcription Can Produce Different Kinds of RNA Molecules
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Transcription
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

