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[Neurological disorder associated to EBV: three case reports].

S Luchi1, L Del Bono, A Vincenti

  • 1U.O. Malattie Infettive, Azienda Ospedaliera Pisana, Pisa, Italy.

Le Infezioni in Medicina
|January 1, 1997
PubMed
Summary

Epstein-Barr virus (EBV) can cause serious neurological illness, even without typical infectious mononucleosis symptoms. Early suspicion and diagnosis of EBV are crucial for treating these rare neurological complications.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Context:

  • Epstein-Barr virus (EBV) is linked to diverse clinical outcomes.
  • Neurological involvement (NI) occurs in 1-5% of infectious mononucleosis cases, with isolated NI being rarer.
  • EBV can manifest as various neurological disorders.

Purpose:

  • To report on three cases of neurological involvement as the sole manifestation of Epstein-Barr virus infection.
  • To highlight the importance of considering EBV in acute neurological disorders.
  • To emphasize diagnostic criteria and treatment outcomes.

Summary:

  • Three patients presented with isolated neurological conditions (meningoradiculitis, meningoencephalitis, aseptic meningitis) due to EBV infection.
  • Diagnosis involved lumbar puncture and serological tests (IgM VCA, IgG VCA).

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  • All patients achieved complete remission with dexamethasone, glycerol, and acyclovir treatment.

    • Impact:

    • Recognizing EBV's potential to cause diverse neurological illnesses is critical.
    • Suspecting EBV infection in acute neurological disorders can lead to timely diagnosis and treatment.
    • This study underscores the need for broader consideration of EBV in neurology.