Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stimuli-responsive polypeptide vesicles by conformation-specific assembly.

Enrico G Bellomo1, Michael D Wyrsta, Lisa Pakstis

  • 1Department of Materials, University of California, Santa Barbara, California 93106, USA.

Nature Materials
|March 23, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced Diffusion and Retention of Proteoglycan Replacements in Cartilage through Thermoresponsive Polyelectrolytes.

Macromolecules·2026
Same author

Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions.

Biomaterials science·2026
Same author

Terminal-Directed Supramolecular Liquid Crystal Formation by Designed Coiled-Coil Interparticle Stacking.

ACS nano·2026
Same author

Patchy peptide particles for pH-responsive assembly into liquid crystals or lattices.

Science (New York, N.Y.)·2026
Same author

Electrostatic Coassembly of Coiled-Coil Peptide Bundlemers with Complementary Charges into Porous 2D Lattices.

Journal of the American Chemical Society·2025
Same author

Designed coiled-coil peptide nanoparticles with tunable self-assembly: distinct ordered nanostructures <i>via</i> nonnatural side chain modification and electrostatic screening.

Soft matter·2025
Same journal

Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development.

Nature materials·2026
Same journal

Electron-phonon coupling and symmetry breaking in superconducting oxide interfaces near ferroelectric quantum criticality.

Nature materials·2026
Same journal

Giant and broadband circular dichroism from particle-hole symmetry breaking in Weyl semimetals.

Nature materials·2026
Same journal

Methane storage using metal-dipyrazolate frameworks.

Nature materials·2026
Same journal

Nanotechnology-mediated precision delivery of mRNA.

Nature materials·2026
Same journal

Operando microscopy for neuromorphic hardware.

Nature materials·2026
See all related articles

Researchers created diblock copolypeptides that self-assemble into spherical vesicles, mimicking viral capsid assembly. These novel materials offer tunable size and structure for controlled drug delivery applications.

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Nanotechnology

Background:

  • Lipids and viral proteins naturally form spherical vesicles through self-assembly.
  • Protein subunits' precise folding and conformations dictate viral capsid structure and disassembly.
  • Environmental stimuli, like pH changes, can trigger disassembly of biological structures.

Purpose of the Study:

  • To prepare diblock copolypeptides that self-assemble into spherical vesicular assemblies.
  • To control the size and structure of these assemblies through polymer segment conformations.
  • To incorporate environmental responsiveness for potential drug delivery applications.

Main Methods:

  • Synthesis of diblock copolypeptides.
  • Characterization of self-assembled vesicular structures.

Related Experiment Videos

  • Incorporation of stimuli-responsive functionalities.

    • Main Results:

    • Diblock copolypeptides self-assembled into spherical vesicles.
    • Assembly size and structure were dictated by ordered polymer segment conformations.
    • Vesicles demonstrated susceptibility to environmental stimuli.

    Conclusions:

    • Developed synthetic materials mimicking viral capsid assembly principles.
    • Achieved control over self-assembly and stimuli-responsive function in copolypeptide vesicles.
    • Significant advance towards creating materials for precise three-dimensional assembly and drug delivery.