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1-Phenyl-1H-indazole derivatives with analgesic and anti-inflammatory activities
L Mosti1, L Sansebastiano, P Fossa
1Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|March 1, 1992
Abstract:
The synthesis of 4-hydroxy-1-phenyl-1H-indazole-5-acetic acid 5 4-methoxy-1-phenyl-1H-indazole-5-yl-acetic acid 7 and 5-benzyl-1-phenyl-1H-indazol-4-ol 8, starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one, is described. These compounds showed in mice an analgesic activity superior to that of acetylsalicylic acid and comparable to that of dipyrone; moreover, compound 5 exhibited an appreciable anti-inflammatory activity in rats. Grossbehavioral effects and acute toxicity in mice are also reported.