Related Experiment Video

Updated: Aug 25, 2026

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal

Hans Lassmann1, Richard M Ransohoff

  • 1Division of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria. hans.lassmann@univie.ac.at

Trends in Immunology
|March 24, 2004
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Aug 25, 2026

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Articles linked to this work by shared authors, journal, and citation graph.

Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner.

Journal of immunology (Baltimore, Md. : 1950)·2026

Erythrocyte Fragility in Progressive Multiple Sclerosis.

European journal of neurology·2026

Epstein-Barr Virus Antibodies to Differentiate Multiple Sclerosis From Other Neuroinflammatory Diseases.

JAMA neurology·2026

Characteristic patterns of complement deposition in NMOSD, MOGAD, and MS.

Acta neuropathologica·2026

The dynamics of brain T cell populations during the course of rasmussen encephalitis: from expansion to exhaustion.

Journal of neuroinflammation·2025

Subcortical plaques and inflammation reflect cortical and meningeal pathologies in progressive multiple sclerosis.

Brain pathology (Zurich, Switzerland)·2024

Eating to heal: dietary interventions as emerging immune-based therapeutic strategies.

Trends in immunology·2026

Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery.

Trends in immunology·2026

Tracking tumor and immune remodeling through myeloma therapy.

Trends in immunology·2026

Micrometastasis as a distinct immunobiological state and therapeutic target.

Trends in immunology·2026

Neutrophil-T cell dynamics predict tuberculosis outcome.

Trends in immunology·2026

CARM1: an epigenetic brake on cDC1-mediated antitumor immunity.

Trends in immunology·2026

Intraosseous venous malformation of the clivus.

BMJ case reports·2026

Validating the neurobiological model of obsessive-compulsive disorder: a brain entropy study using resting-state fMRI.

Progress in neuro-psychopharmacology & biological psychiatry·2026

The Choroidal Nervous System as an Integrative Neuroendocrine-Neurovascular Node in Central Serous Chorioretinopathy: A Reply.

Progress in retinal and eye research·2026

Repetitive transcranial magnetic stimulation for autism spectrum disorder: A systematic review and meta-analysis of treatment regimens, efficacy, and safety.

Psychiatry research·2026

Early trajectory of white matter development in nonsyndromic craniosynostosis compared with neurotypical infants: a 3-site diffusion tensor imaging study.

Journal of neurosurgery. Pediatrics·2026

Prevalence and clinical characterization of headache in patients with cranial bone defects: a single-center retrospective study.

Acta neurologica Belgica·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us