Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural proteomics: a tool for genome annotation.

Alexander F Yakunin1, Adelinda A Yee, Alexei Savchenko

  • 1Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada.

Current Opinion in Chemical Biology
|March 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

ABHD2 activity is not required for the non-genomic action of progesterone on human sperm.

Human reproduction (Oxford, England)·2026
Same author

Polycationic nanopeptide-fused endolysins for the control of Mannheimia haemolytica.

Applied microbiology and biotechnology·2026
Same author

A Bifunctional T3SS-Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS-3.

The FEBS journal·2026
Same journal

Function through shape: An overview of DNA G-quadruplexes in transcriptional regulation.

Current opinion in chemical biology·2026
Same journal

Advances in tools and technologies for multiplexed bioluminescence imaging.

Current opinion in chemical biology·2026
Same journal

High-resolution molecular mapping by expansion-coupled label-free and multimodal imaging.

Current opinion in chemical biology·2026
Same journal

Recent advances in glycoconjugate-based therapeutics.

Current opinion in chemical biology·2026
Same journal

Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.

Current opinion in chemical biology·2026
Same journal

Chemigenetic fluorescent biosensors in biological imaging - New trends and advances.

Current opinion in chemical biology·2026
See all related articles

Structural genomics aids in understanding gene function by analyzing protein structures. Integrating structural data with bioinformatics and experiments accelerates the discovery of molecular functions.

Area of Science:

  • Genomics
  • Structural Biology
  • Bioinformatics

Background:

  • A significant portion of genes in newly sequenced genomes (30-50%) have unknown functions.
  • Structural genomics offers a powerful strategy for functional annotation of these genes.

Purpose of the Study:

  • To highlight the role of structural genomics in deciphering protein function.
  • To emphasize the integration of structural data with other approaches for enhanced functional annotation.

Main Methods:

  • High-throughput structure generation in structural genomics projects.
  • Identification of novel structural motifs involved in catalysis and ligand binding.
  • Integration of structural information with bioinformatics and experimental screening (enzymatic activity, ligand binding).

Related Experiment Videos

Main Results:

  • Structural genomics is rapidly generating a large number of new protein structures.
  • New structural motifs with roles in enzymatic catalysis and macromolecular binding have been identified.
  • Combining structural data with bioinformatics and experimental methods improves functional inference.

Conclusions:

  • Structural genomics is a key approach for assigning function to uncharacterized proteins.
  • Integrating structural data with computational and experimental methods enhances the efficiency of functional annotation.