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Protein sequence databases.

Rolf Apweiler1, Amos Bairoch, Cathy H Wu

  • 1The EMBL Outstation-The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. apweiler@ebi.ac.uk

Current Opinion in Chemical Biology
|March 24, 2004
PubMed
Summary
This summary is machine-generated.

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Protein sequence databases are crucial for research, evolving from simple repositories to comprehensive, curated resources. The Universal Protein Knowledgebase (UniProt) is highlighted as a leading example.

Area of Science:

  • Bioinformatics
  • Proteomics
  • Genomics

Background:

  • Protein sequence databases are essential resources for biological research.
  • These databases range from basic sequence repositories to expertly curated universal databases.
  • The importance of protein databases is increasing as research shifts from genomes to proteins.

Purpose of the Study:

  • To discuss leading protein sequence databases.
  • To emphasize the resources provided by the Universal Protein Knowledgebase (UniProt) consortium.

Main Methods:

  • Review of existing protein sequence databases.
  • Comparative analysis of database types (simple repositories vs. curated universal databases).

Main Results:

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  • Identification of different types of protein sequence databases.
  • Highlighting the comprehensive nature and enhanced information in curated databases.
  • Recognition of the Universal Protein Knowledgebase (UniProt) as a key resource.

Conclusions:

  • Protein sequence databases are vital and evolving resources for the scientific community.
  • Curated universal databases offer significant advantages for protein information retrieval.
  • The Universal Protein Knowledgebase (UniProt) represents a leading platform in this field.