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Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
Effects of hydrogen peroxide on contraction of skinned aorta from guinea pigs
Wataru Sakurai1, Masaru Watanabe, Akira Yamashina
1Second Department of Internal Medicine, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-0023 Japan. celsior@vc.kcom.ne.jp
Abstract:
We examined the effects of hydrogen peroxide (H2O2) on the contractile force of cell membrane permeabilized descending thoracic aorta from guinea pigs. H2O2 enhanced generated force in the Ca2+-induced contraction at any given concentration of Ca2+, and maintained force level in the 30 mM Mg2+-induced Ca2+-independent force maintenance. H2O2 seems to directly enhance the cross-bridge interaction of aortic smooth muscles.
