Cyclosporine in renal transplantation: a Scottish experience

The renal transplant unit in Glasgow has performed over 1500 renal transplants since the introduction of cyclosporine (CyA) in 1984. We extracted data on all renal transplants from cadaveric donors, where the recipient received primary immunosuppression with CyA, between 1984 and 2002. A total of 1262 transplants were analyzed in four eras (1984-1988, 1989-1992, 1993-1996, 1997-2002). Over this time period we observed progressive improvement in graft and patient survival, with the clearest improvements coinciding with the introduction of the Neoral formulation of CyA.