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Related Experiment Videos

Combination tramadol plus acetaminophen for postsurgical pain.

Adam B Smith1, Thanjavur S Ravikumar, Marc Kamin

  • 1Department of Surgery, University of North Texas Health Science Center, 855 Montgomery St., Fort Worth, TX 76107, USA. adsmith@hsc.unt.edu

American Journal of Surgery
|March 26, 2004
PubMed
Summary
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Tramadol plus acetaminophen effectively managed postsurgical pain compared to placebo. This combination demonstrated better tolerability than codeine plus acetaminophen for orthopedic and abdominal pain relief.

Area of Science:

  • Pharmacology
  • Pain Management
  • Clinical Trials

Background:

  • Multicenter, randomized, double-blind, placebo-controlled trial.
  • Evaluated tramadol plus acetaminophen (APAP) for orthopedic and abdominal postsurgical pain.

Purpose of the Study:

  • To assess the efficacy and tolerability of tramadol plus APAP for postsurgical pain.
  • Compared tramadol/APAP to codeine/APAP and placebo.

Main Methods:

  • Patients with moderate to severe pain randomized to tramadol/APAP, codeine/APAP, or placebo.
  • Medication administered as initial two tablets, then 1-2 tablets every 4-6 hours for 6 days.
  • Outcome measures included pain relief, pain intensity, and adverse events.

Main Results:

Related Experiment Videos

  • Tramadol/APAP superior to placebo for total pain relief and pain intensity (P <= 0.015).
  • Tramadol/APAP and codeine/APAP showed similar efficacy (P >= 0.281).
  • Tramadol/APAP demonstrated better tolerability than codeine/APAP, with fewer adverse events like constipation and vomiting.

Conclusions:

  • Tramadol plus APAP is effective and well-tolerated for postsurgical pain.
  • Tramadol/APAP showed superior tolerability compared to codeine/APAP.
  • The combination is a viable option for managing postsurgical pain.