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Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
[Multiple actinomycosis brain abscesses]
J Liotier1, C Venet, M-L Chambonnière
1Service de réanimation polyvalente, hôpital Bellevue, Saint-Etienne. jliotier@chu-clermontferrand.fr
Background:
Actinomycosis is a subacute or chronic bacterial infection, which can affect immunocompetent or immunodeficient subjects. It most often occurs in cervico-facial or thoracic-abdominal locations. Central nervous system infection is rare but of severe prognosis.
Case Report:
A 56 year-old woman with no history of immunodepression was admitted with unexplained fever, inappropriate behaviour, and spatial and temporal disorientation. The progressive worsening of the neurological signs let to coma and mechanical ventilation was required. Brain imaging showed multilocation cerebral abscesses. Stereotaxial biopsy permitted diagnosis of actinomycosis. Patient's outcome was favourable following appropriate dual antibiotherapy without surgical exeresis.
Discussion:
When lacking bacteriologic identification, diagnosis of cerebral actinomycosis is performed by pathologic findings. Dual antibiotherapy allows full recover, even in the case of multilocation cerebral abscesses.
Insights
Central nervous system actinomycosis, a rare bacterial infection, can lead to severe neurological symptoms. Prompt diagnosis and dual antibiotic therapy can result in a full recovery, even with multiple brain abscesses.
Area of Science:
- Neurology
- Infectious Diseases
- Microbiology
Background:
- Actinomycosis is a subacute or chronic bacterial infection affecting both immunocompetent and immunodeficient individuals.
- Commonly presents in cervico-facial or thoracic-abdominal regions, with rare but severe central nervous system (CNS) involvement.
Observation:
- A 56-year-old woman presented with fever, behavioral changes, and disorientation, progressing to coma.
- Brain imaging revealed multiple cerebral abscesses, and stereotactic biopsy confirmed actinomycosis.
Findings:
- Diagnosis of cerebral actinomycosis can be established through pathological findings when bacteriologic identification is challenging.
- The patient experienced a favorable outcome with dual antibiotic therapy, without requiring surgical intervention.
Implications:
- Dual antibiotherapy is effective for treating multilocation cerebral actinomycosis.
- Highlights the importance of considering actinomycosis in CNS infections presenting with abscesses, even in immunocompetent patients.
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