Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adipose tissue-derived stromal cells express neuronal phenotypes.

Li-ye Yang1, Xiang-ming Liu, Bing Sun

  • 1Department of Neurosurgery, First Affiliated Hospital, Suzhou University, Suzhou 215006, China. yangleeyee@sina.com

Chinese Medical Journal
|March 27, 2004
PubMed
Summary

Adipose tissue-derived stromal cells (ADSCs) can differentiate into neuron-like cells. This suggests ADSCs are a potential source for central nervous system (CNS) cell transplantation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.

Plant physiology·2020
Same author

Corrigendum to "Low-background electrochemical biosensor for one-step detection of base excision repair enzyme" [Biosens. Bioelectr. 150 (2020) 11865].

Biosensors & bioelectronics·2020
Same author

Corrigendum to "A dual signal-on photoelectrochemical immunosensor for sensitively detecting target avian viruses based on AuNPs/g-C<sub>3</sub>N<sub>4</sub> coupling with CdTe quantum dots and in situ enzymatic generation of electron donor" [Biosens. Bioelectron. 124-125 (2019) 1-7 Article Number: BIOS10843].

Biosensors & bioelectronics·2020
Same author

ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation.

Proceedings of the National Academy of Sciences of the United States of America·2020
Same author

Correction: β-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes.

Journal of immunology (Baltimore, Md. : 1950)·2020
Same author

An optimized double T-DNA binary vector system for improved production of marker-free transgenic tobacco plants.

Biotechnology letters·2020

Area of Science:

  • Stem cell biology
  • Neuroscience
  • Tissue engineering

Background:

  • Adipose tissue-derived stromal cells (ADSCs) are multipotent mesenchymal stem cells.
  • ADSCs can be expanded in vitro and differentiated into various cell types.

Purpose of the Study:

  • To investigate the potential of ADSCs to differentiate into neurons.
  • To explore ADSCs as an alternative stem cell source for CNS transplantation.

Main Methods:

  • Rat adipose tissue was processed to isolate ADSCs.
  • Cells were cultured in a low-fetal bovine serum medium to induce differentiation.
  • Immunocytochemistry and RT-PCR were used to identify cell markers and gene expression (NF1, nestin, NSE).

Main Results:

Related Experiment Videos

  • ADSCs expressed nestin and neuron-specific enolase (NSE) mRNA, but not neurofilament 1 (NF1) mRNA.
  • Cells cultured in low-serum medium exhibited neuron-like morphologies.
  • Nestin-positive cells were observed within the ADSC cultures.

Conclusions:

  • ADSCs possess the capacity to differentiate into neuron-like cells.
  • These findings support ADSCs as a potential autologous stem cell source for CNS repair and regeneration.