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Intracerebral transplants of primary muscle cells: a potential 'platform' for transgene expression in the brain
1Department of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin, Madison 53706.
Brain Research
|March 13, 1992
Abstract:
After the transplantation of rat primary muscle cells into the caudate or cortex of recipient rats, the muscle cells were able to persist for at least 6 months. Muscle cells transfected with expression plasmids prior to transplantation were able to express reporter genes in the brains for at least 2 months. These results suggest that muscle cells might be a useful 'platform' for transgene expression in the brain.